At least when it relates to his 'simulation argument, Bostrom raises some strong points.
I've tried to come up with my own 7-point process of staged contradiction, in order to try and disprove the simulation argument. And, I cannot.
I am of the opinion that we must wrangle more with these particular propositions highlighted. And that we must expend the time/energy/resources in order to be able to further peer into the nature (fabric) of reality. As well, continue to unearth the mechanism through which we will continue learning about our consciousness.
The making of these comment, is not so suggest that I endorse Bostrom's opinion about a whole range of issues. In particular, the issue, the claim, that certain technologies must be deliberately retarted.